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KMID : 0545120160260071198
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Journal of Microbiology and Biotechnology
2016 Volume.26 No. 7 p.1198 ~ p.1205
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Lipoteichoic Acid Isolated from Weissella cibaria Increases Cytokine Production in Human Monocyte-Like THP-1 Cells and Mouse Splenocytes
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Hong Yi Fan
Lee Yoon-Doo
Park Jae-Yeon
Kim Seong-Jae
Lee Youn-Woo
Jeon Bo-Ram
Jagdish Deepa
Kim Han-Geun
Chung Dae-Kyun
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Abstract
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Lactic acid bacteria (LAB) have beneficial effects on intestinal health and skin diseases. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is known to induce the production of several cytokines such as TNF-α, IL-1β, and IL-8 and affect the intestinal microflora, anti-aging, sepsis, and cholesterol level. In this study, Weissella cibaria was isolated from Indian dairy products, and we examined its immune-enhancing effects. Live and heatkilled W. cibaria did not induce the secretion of immune-related cytokines, whereas LTA isolated from W. cibaria (cLTA) significantly increased the secretion of TNF-α, IL-1β, and IL-6 in a dose-dependent manner. cLTA increased the phosphorylation of nuclear factor kappalight- chain-enhancer of activated B cells, p38 mitogen-activated protein kinases, and c-Jun Nterminal kinases in THP-1 cells. The secretion of TNF-α and IL-6 was also increased in the cLTA-treated mouse splenocytes. These results suggest that cLTA, but not W. cibaria whole cells, has immune-boosting potential and can be used to treat immunosuppression diseases.
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KEYWORD
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Weissella cibaria, Cytokine, Lipoteichoic acid, Immune regulation
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